Grambling State and Southern University will be back in the Superdome Saturday for the annual Bayou Classic.
Fans of both schools are already arriving in New Orleans ready to cheer on their teams.
City officials are estimating 250,000 people will be here for the game.
The city is expecting a $50 million economic boost this weekend.
The events will be kicking off at 1 p.m. Friday with the Bayou Classic Biztech Challenge. This is a technology competition that will have students pitching business ideas for a grand prize of $10,000.
At 5 p.m. there will be a greek show followed by the battle of the bands.
Before the game Saturday there will also be a parade from the French market to the Superdome followed by live music headlined by Grammy award winning rapper T.I.
"The unique thing about the Bayou Classic is I have been the little kid that have cheered on the university to victory, but then I have also been the player on the field," said Broderick Fobbs, Grambling State head coach. "Now I get to be the coach on the sidelines.
Just like last year, the SWAC western title will be on the line tomorrow, and both coaches say they're ready for the big game.
"I really think that we're going to have a scheme this year that our guys are going to be able to communicate to each other because they're older and really be able to play a lot better," said Dawson Odums, Southern University head coach.
The Bayou Classic will kick off Saturday at the Superdome at 4 p.m.
Tickets are still on sale for the game for just $16 each.